1. Introducción. Historia, desde los orígenes a la Baja Edad Media -- 2. Historia, desde el Renacimiento a la actualidad.

On 26 June 2000, during the presentation of the Human Genome Project's first draft, Bill Clinton, then President of the United States, claimed that "today we are learning the language in which God created life".1 Behind his remarks lay a story of more than half a century involving the understanding of DNA as information. This paper analyses that story, discussing the origins of the informational view of our genes during the early 1950s, how such a view affected the research on (...) the genetic code (1950s and '60s) and the transformation of the information idea in the context of DNA sequencing and bioinformatics ('80s and '90s). I suggest that the concept of DNA as information reached a climax with the proposal of the Human Genome Project (HGP), but is currently facing a crisis coinciding with the questioning of the information society. Finally, I discuss the emergence of systems biology as an alternative paradigm. (shrink)

From March to September 2020, researchers working at a biomedical scientific campus in Spain faced two lockdowns and various mobility restrictions that affected their social and professional lifestyles. The working group “Women in Science,” which acts as an independent observatory of scientific gender inequalities on campus launched an online survey to assess the impact of COVID-19 lockdowns on scientific activity, domestic and caregiving tasks, and psychological status. The survey revealed differences in scientific performance by gender: while male researchers participated in (...) a larger number of scientific activities for career development, female researchers performed more invisible scientific tasks, including peer review or outreach activities. Mental impact was greater in researchers caring for children or dependents, and this was aggravated for women. Results spot a disproportionate impact of COVID-19 lockdowns on female scientific career development, and urges for equity measures to mitigate the consequences of an increase in the gender gap in biomedical sciences for current and future pandemics. (shrink)

Fred Sanger, the inventor of the first protein, RNA and DNA sequencing methods, has traditionally been seen as a technical scientist, engaged in laboratory bench work and not interested at all in intellectual debates in biology. In his autobiography and commentaries by fellow researchers, he is portrayed as having a trajectory exclusively dependent on technological progress. The scarce historical scholarship on Sanger partially challenges these accounts by highlighting the importance of professional contacts, institutional and disciplinary moves in his career, spanning (...) from 1940 to 1983. This paper will complement such literature by focusing, for the first time, on the transition of Sanger’s sequencing strategies from degrading to copying the target molecule, which occurred in the late 1960s as he was shifting from protein and RNA to DNA sequencing, shortly after his move from the Department of Biochemistry to the Laboratory of Molecular Biology, both based in Cambridge (UK). Through a reinterpretation of Sanger’s papers and retrospective accounts and a pioneering investigation of his laboratory notebooks, I will claim that sequencing shifted from the working procedures of organic chemistry to those of the emergent molecular biology. I will also argue that sequencing deserves a history in its own right as a practice and not as a technique subordinated to the development of molecular biology or genomics. My proposed history of sequencing leads to a reappraisal of current STS debates on bioinformatics, biotechnology and biomedicine. (shrink)

This article proposes a new bi-directional way of understanding the convergence of biology and computing. It argues for a reciprocal interaction in which biology and computing have shaped and are currently reshaping each other. In so doing, we qualify both the view of a natural marriage and of a digital shaping of biology, which are common in the literature written by scientists, STS, and communication scholars. The DNA database is at the center of this interaction. We argue that DNA databases (...) are spaces of convergence for computing and biology that change in form, meaning, and function from the 1960s to the 2000s. The first part of the article shows how, in the 1980s, DNA sequencing shifted from passively incorporating computers to be increasingly modeled in digital coding and decoding. Information retrieval algorithms, reciprocally, were altered according to the peculiarities of DNA in the first sequence-storage databases. The second part of the article investigates the impact of these reciprocal interactions and globalization on the organization of research centers, ways of conducting big science, and scientific values. Through convergence and new technologies such as data mining, biology and computing were transformed technologically, institutionally, and culturally into a new bio-data enterprise called genomics. (shrink)

This paper addresses the 1996 cloning of Dolly the sheep, locating it within a long-standing tradition of animal breeding research in Edinburgh. Far from being an end in itself, the cell-nuclear transfer experiment from which Dolly was born should be seen as a step in an investigative pathway that sought the production of medically relevant transgenic animals. By historicising Dolly, I illustrate how the birth of this sheep captures a dramatic redefinition of the life sciences, when in the 1970s and (...) 1980s the rise of neo-liberal governments and the emergence of the biotechnology market pushed research institutions to show tangible applications of their work. Through this broader interpretative framework, the Dolly story emerges as a case study of the deep transformations of agricultural experimentation during the last third of the twentieth century. The reorganisation of laboratory practice, human resources and institutional settings required by the production of transgenic animals had unanticipated consequences. One of these unanticipated effects was that the boundaries between animal and human health became blurred. As a result of this, new professional spaces emerged and the identity of Dolly the sheep was reconfigured, from an instrument for livestock improvement in the farm to a more universal symbol of the new cloning age. -/- . (shrink)

Fred Sanger, the inventor of the first protein, RNA and DNA sequencing methods, has traditionally been seen as a technical scientist, engaged in laboratory bench work and not interested at all in intellectual debates in biology. In his autobiography and commentaries by fellow researchers, he is portrayed as having a trajectory exclusively dependent on technological progress. The scarce historical scholarship on Sanger partially challenges these accounts by highlighting the importance of professional contacts, institutional and disciplinary moves in his career, spanning (...) from 1940 to 1983. This paper will complement such literature by focusing, for the first time, on the transition of Sanger's sequencing strategies from degrading to copying the target molecule, which occurred in the late 1960s as he was shifting from protein and RNA to DNA sequencing, shortly after his move from the Department of Biochemistry to the Laboratory of Molecular Biology, both based in Cambridge (UK). Through a reinterpretation of Sanger's papers and retrospective accounts and a pioneering investigation of his laboratory notebooks, I will claim that sequencing shifted from the working procedures of organic chemistry to those of the emergent molecular biology. I will also argue that sequencing deserves a history in its own right as a practice and not as a technique subordinated to the development of molecular biology or genomics. My proposed history of sequencing leads to a reappraisal of current STS debates on bioinformatics, biotechnology and biomedicine. (shrink)

This paper explores the different identities adopted by connective tissue research at the University of Manchester during the second half of the 20th century. By looking at the long-term redefinition of a research programme, it sheds new light on the interactions between different and conflicting levels in the study of biomedicine, such as the local and the global, or the medical and the biological. It also addresses the gap in the literature between the first biomedical complexes after World War II (...) and the emergence of biotechnology. Connective tissue research in Manchester emerged as a field focused on new treatments for rheumatic diseases. During the 1950s and 60s, it absorbed a number of laboratory techniques from biology, namely cell culture and electron microscopy. The transformations in scientific policy during the late 70s and the migration of Manchester researchers to the US led them to adopt recombinant DNA methods, which were borrowed from human genetics. This resulted in the emergence of cell matrix biology, a new field which had one of its reference centres in Manchester. The Manchester story shows the potential of detailed and chronologically wide local studies of patterns of work to understand the mechanisms by which new biomedical tools and institutions interact with long-standing problems and existing affiliations. (shrink)

Miguel de Unamuno celebra la locura del Quijote como una afirmación del “yo” en su Vida de don Quijote y Sancho. Para G.K. Chesterton la afirmación radical del “yo” es el elemento fundamental de la locura, pero no algo para ser celebrado. Para Chesterton la locura del Quijote no está tanto en la afirmación de su propio “yo” sino en la afirmación de una realidad olvidada, invisible para quienes se han acostumbrado a vivir en un mundo que ha (...) perdido el juicio: es el único cuerdo en un mundo de locos. Elementos de esta lectura del Quijote pueden encontrarse, a pesar de Unamuno, en la Vida de don Quijote y Sancho; es Unamuno, más que el Quijote, quien afirma su “yo” a costa de la realidad. (shrink)

Este artículo aborda dos temáticas de la novela La muerte es una vieja historia de Hernán Rivera Letelier: la construcción de la identidad de la mujer pentecostal y el uso de la música tanto en el templo como en la vida de un fiel pentecostal. En el primer apartado abordamos tres aspectos del primer tema relacionados con la mujer pentecostal: la inteligencia social y cognitiva, la corporalidad y sensualidad, y la violencia sexual. En el segundo apartado hacemos referencia a la (...) importancia que tiene la música en los templos y la vida cotidiana de los pentecostales, que en la novela se refleja en las anécdotas y experiencias que se cuentan de la protagonista, la hermana Tegualda. (shrink)

“The crowns and scepters of stage emperors,” remarked Sancho, “were never known to be of pure gold; they are always of tinsel or tinplate.” “That is the truth,” said Don Quixote, “for it is only right that the accessories of a drama should be fictitious and not real, like the play itself. Speaking of that, Sancho, I would have you look kindly upon the art of the theater and, as a consequence, upon those who write the pieces and (...) perform in them, for they render a great service to the state by holding up a mirror for us at each step we take, wherein we may observe, vividly depicted, all the varied aspects of human life; and I may add that there is nothing that shows us more clearly, by similitude, what we are and what we ought to be than do plays and players.” Miguel de Cervantes,Don Quixote, II, iii, 12. (shrink)

El presente artículo ofrece una traducción anotada del _Tratado acerca de las reglas del arte de los poetas_ (_Qawānīn fī ṣināʿat al-šuʿarāʾ_) de Abū Naṣr al-Fārābī. Acompañamos esta traducción de una introducción dividida en tres partes. En primer lugar, se ofrece un contexto general acerca del lugar del Qawānīn en la obra de al-Fārābī y en la tradición filosófica árabe. En segundo, se plantea una posible división temática del texto. Y finalmente, en tercer lugar, se especifican las peculiaridades de la (...) traducción, referente al texto tomado como base y las principales decisiones de traducción. (shrink)

¿Podemos llamar madre a Dios? Responder a esta pregunta es lo que tratamos de hacer en las siguientes líneas partiendo del estudio de la raíz hebrea "rhm", cuyo significado original es "útero". Comenzamos haciendo un rápido repaso del significado del término y de sus palabras derivadas en los textos bíblicos. Nos centramos en el uso del término por el profeta Isaías y -especialmente- por el profeta de la Consolación. Así, parece que concebir y entender a Dios como madre es algo (...) que forma parte de la revelación. (shrink)

Miguel Angel Muñoz brings together in this book several inteviews he made over more than two decades in England, France, Spain and Mexico. These conversations complete and close a cycle, not of creation, but of the exercise of conversing with multiple creators: poets, historians, anthropologists and novelists. These are works that he believes coincide in an identical aesthetic conviction: they insist on concern not only for creativity but also for the complex social and cultural history that we live in (...) the world of yesterday and today. (shrink)

RESUMEN Aunque la educación superior cubana constituye un espacio privilegiado para la atención a la diversidad cultural, se identifica la carencia de una concepción de la interculturalidad desde el sujeto que vive la experiencia y cuya cultura de origen se instaura como dimensión mediatizadora de la relación con respecto a otros; carencia no abordada en profundidad a través del prisma de la sicología social. En este orden se realizó una revisión bibliográfica con el objetivo de profundizar en el enfoque sicosocial (...) expresivo de las relaciones interculturales contextualizadas en la enseñanza médica superior cubana; la misma, contribuyó a la comprensión de la expresión subjetiva conformada alrededor de la realidad objeto de estudio. Los resultados permitieron construir un cuerpo teórico descriptivo-explicativo de las emergencias subjetivas que adquieren su especificidad en las relaciones interculturales desde un compromiso práctico y axiológico. A modo de conclusiones se estableció que en la búsqueda de un campo académico unificado y coherente con la complejidad de la realidad objeto de estudio, la sicología social deviene tributaria de un enfoque centrado en el estudio de las formas de subjetividad social que median en las relaciones interculturales desde el contexto de la enseñanza médica superior cubana. ABSTRACT Even though Cuban higher education is a privileged space for the attention of cultural diversity, the lack of an intercultural conception from the person who lives the experience and whose home culture is established as an interfering dimension in his relationship with others is identified; a problem which is not dealt with in depth through the perspective of social psychology. Therefore, a bibliographic review was made in order to go into depth in the expressive psychosocial approach to intercultural relationships put in context in Cuban higher medical education. It contributed to the understanding of the subjective expression which makes the reality of the object of study. The results allowed to make a descriptive-explanatory theoretical body of the subjective emergencies which become specific in intercultural relationships from a practical and axiological commitment. As a conclusion, it was established the search of an academic field which can be unifying and coherent with the complexity of the reality object of study. Social psychology becomes tributary of an approach that is centered in the study of social subjectivity forms that mediate in intercultural relationships from the context of Cuban higher medical education. (shrink)

El poshumanismo y transhumanismo representa varias y distintas corrientes de pensamiento que ponen de relieve la relación entre la tecnología y los seres humanos actualizando la pregunta acerca de qué es el ser humano. Algunas de estas propuestas sugieren que la tecnología será capaz de vencer todos los límites humanos, e incluso, los humanos serán capaces de conseguir la inmortalidad tecnológica. Pero, una mirada a lo que el ser humano es, indica la necesidad de comprenderlo como frágil y vulnerable. Existe (...) un riesgo de deshumanización en la aplicación de las tecnologías si la vulnerabilidad humana no se tiene en cuenta. (shrink)

In this essay we take stock of the shortcomings, successes, and promises of ‘biopolitics' to understand and frame global health crises such as COVID-19. We claim that rather than thinking in terms of a special relationship between Western modernity and biopolitics, it is better to look at a longer and more global histories of populations’ politics of life and health to situate present and future responses to ecological crises. Normatively, we argue for an affirmative biopolitics, that at once de-securitizes our (...) approach to our biosocial condition and expands the politics of the human estate to other molar and molecular dimensions. (shrink)

Un a d e la s proclama s má s escuchada s e n la s concentracione s de l 15- M e s qu e los ca r go s político s n o no s r ep r esentan . P ar a v eri f ca r s i es e reproch e est á justi f icado , e n este estudi o analizamo s primer o qu é deb e se r l a representació n (...) polític a e n u n Estad o democrático ; a continuación , y par a sabe r s i lo s representante s “no s representan” , no s f ijamos e n l a fo r m a e n qu e ha n sid o el e gidos , e n e l mod o e n e l qu e ejerce n s u funció n y e n las pre r r o gat iv a s que , e n teoría , garantiza n e l ejercici o d e es a función. (shrink)

Este es un relato de creación literaria.

Este trabajo parte de la entrevista realizada a Rafael Courtoisie, tesorero de la Academia Nacional de Letras de Uruguay. El propósito de este manuscrito consistió en que el intelectual brindara un panorama de la producción literaria de su país a lo largo de la historia. Asimismo, su trayectoria que tiene como investigador y crítico de la Literatura permitió que pudiera ahondar en valoraciones que atañen a temas un tanto controversiales, como los pueden ser las entregas del Premio Nobel de Literatura, (...) la consolidación y la permanencia de un canon representativo en cada país o la realización de propuestas novedosas en torno a autores clásicos, como Dante Alighieri. (shrink)

Esta entrevista se realizó en dos sesiones vía Zoom, cuyas fechas están ubicadas en agosto de 2021. La primera conversación que se tuvo consistió en que el filósofo Modesto Gómez Alonso brindara unas ideas panorámicas y reflexivas, las cuales se han colocado al inicio de cada resolución. Entretanto, en la segunda conversación, se partió de lo planteado anteriormente y de algunos apuntes que permitieron esbozar de una forma más contundente las respuestas. Todo este procedimiento sirvió para que se pudiera tratar (...) sobre la noción de la epistemología desde sus múltiples manifestaciones. Es por eso por lo que el filósofo Modesto Gómez recurrió a concepciones afines, como aquellas que proporcionan el conocimiento, al igual que buscó explicar con mayor detalle al citar a autores como Descartes, Sosa, entre otros. En ese sentido, esta entrevista tuvo el propósito de buscar las conexiones que existen de la Filosofía con la vida cotidiana en cuanto a que se indaga de las posibilidades de contribuir al conocimiento y contar con las herramientas adecuadas. (shrink)

Phenomenology in medicine’s main contribution is to present a first-person narrative of illness, in an effort to aid medicine in reaching an accurate disease diagnosis and establishing a personal relationship with patients whose lived experience changes dramatically when severe disease and disabling condition is confirmed. Once disease is diagnosed, the lived experience of illness is reconstructed into a living-with-disease narrative that medicine’s biological approach has widely neglected. Key concepts like health, sickness, illness, disease and the clinical encounter are being diversely (...) and ambiguously used, leading to distortions in socio-medical practices such as medicalization, pharmaceuticalization, emphasis on surveillance medicine. Current definitions of these concepts as employed in phenomenology of medicine are revised, concluding that more stringent semantics ought to reinforce an empirical phenomenological or postphenomenological approach. (shrink)